Skip to Content
34 questions
Show Answers
See Preview
- 1. Open-ended30 seconds1 ptWhat is the overall heritability of depressive illness? (percentage)
- 2. Open-ended30 seconds1 ptDepression follows Mendelian or polygenic inheritance?
- 3. Open-ended30 seconds1 ptTrue/False: Re depression, there is no one to one correspondence between genotype and phenotype
- 4. Open-ended30 seconds1 ptRe depression, describe the relationship between your DNA, epigenetic changes, stochastic events, environmental affects, and phenotype
- 5. Open-ended30 seconds1 ptDescribe the association between childhood maltreatment and adult depression, as a function of 5-HTT genotype
- 6. Open-ended30 seconds1 ptTrue/False: Short versions of the 5-HTT genotype are protective against depression.
- 7. Open-ended30 seconds1 ptTrue/False: Childhood stress/trauma does not have a statistically significant effect on probability of adult depression.
- 8. Open-ended30 seconds1 ptDisturbances in which three neurotransmitters play a role in depression?
- 9. Open-ended30 seconds1 ptWhere is serotonin produced?
- 10. Open-ended30 seconds1 ptWhat three activities does serotonin regulate?
- 11. Open-ended30 seconds1 ptWhat happens to people who are deprived of tryptophan?
- 12. Open-ended30 seconds1 ptWhere is norepinephrine produced?
- 13. Open-ended30 seconds1 ptWhat three activities does norepinephrine regulate?
- 14. Open-ended30 seconds1 ptWhy is there is a high rate of comorbidity of Parkinson's disease and depression?
- 15. Open-ended30 seconds1 ptWhat is true regarding the dopamine transporter binding potential in the bilateral striatum of depressed patients?
- 16. Open-ended30 seconds1 ptFailure to cope with stress can activate which center in the brain that regulates endocrine function?
- 17. Open-ended30 seconds1 ptChronic HPA axis activation due to stress can lead to desensitization of receptors for which hormone?
- 18. Open-ended30 seconds1 ptWhat is the consequence of desensitization of cortisol receptors on hormonal feedback control?
- 19. Open-ended30 seconds1 ptWhat is the consequence of chronic hyper secretion of cortisol on the immune system?
- 20. Open-ended30 seconds1 ptWhat is the consequence of desensitization of cortisol receptors on neurotransmitter function?
- 21. Open-ended30 seconds1 ptList the consequences of chronic hyper secretion of CRF/cortisol (due to stress and subsequent HPA axis activation)
- 22. Open-ended30 seconds1 ptHow do depressed patients respond to the dexamethasone test?
- 23. Open-ended30 seconds1 ptDo depressed patients have more or less CRH (corticotropin releasing hormone) neurons than normal?
- 24. Open-ended30 seconds1 ptWhat is the principal source of brain CRH?
- 25. Open-ended30 seconds1 ptWhat happens in animals if CRF is injected into the brain?
- 26. Open-ended30 seconds1 ptDo depressed patients have larger or smaller pituitary/adrenal glands?
- 27. Open-ended30 seconds1 ptTrue/False: CRH receptor polymorphisms interact with degree of childhood abuse in predicting adult depression scores
- 28. Open-ended30 seconds1 ptTrue/False: Cerebral blood flow studies show a decrease in activity in the amygdala, subgenual PFC, medial thalamus, and other brain centers known to be involved in depression
- 29. Open-ended30 seconds1 ptWhy do antidepressants take so long to work?
- 30. Open-ended30 seconds1 ptTrue/False: There is a positive association between childhood maltreatment and biomarkers of inflammation
- 31. Open-ended30 seconds1 ptIFN-alpha was a drug given to cancer patients but a common side effect was depression. Describe two pathophysiological mechanisms by which this occurred.
- 32. Open-ended30 seconds1 ptWhat can be given before treatment with IFN-alpha to reduce the incidence of depression?
- 33. Open-ended30 seconds1 ptName four neurochemical abnormalities that can cause depression
- 34. Open-ended30 seconds1 ptDecreased volume of which 3 areas of the brain are associated with depression?
