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- 1. Open EndedWhat is the overall heritability of depressive illness? (percentage)
- 2. Open EndedDepression follows Mendelian or polygenic inheritance?
- 3. Open EndedTrue/False: Re depression, there is no one to one correspondence between genotype and phenotype
- 4. Open EndedRe depression, describe the relationship between your DNA, epigenetic changes, stochastic events, environmental affects, and phenotype
- 5. Open EndedDescribe the association between childhood maltreatment and adult depression, as a function of 5-HTT genotype
- 6. Open EndedTrue/False: Short versions of the 5-HTT genotype are protective against depression.
- 7. Open EndedTrue/False: Childhood stress/trauma does not have a statistically significant effect on probability of adult depression.
- 8. Open EndedDisturbances in which three neurotransmitters play a role in depression?
- 9. Open EndedWhere is serotonin produced?
- 10. Open EndedWhat three activities does serotonin regulate?
- 11. Open EndedWhat happens to people who are deprived of tryptophan?
- 12. Open EndedWhere is norepinephrine produced?
- 13. Open EndedWhat three activities does norepinephrine regulate?
- 14. Open EndedWhy is there is a high rate of comorbidity of Parkinson's disease and depression?
- 15. Open EndedWhat is true regarding the dopamine transporter binding potential in the bilateral striatum of depressed patients?
- 16. Open EndedFailure to cope with stress can activate which center in the brain that regulates endocrine function?
- 17. Open EndedChronic HPA axis activation due to stress can lead to desensitization of receptors for which hormone?
- 18. Open EndedWhat is the consequence of desensitization of cortisol receptors on hormonal feedback control?
- 19. Open EndedWhat is the consequence of chronic hyper secretion of cortisol on the immune system?
- 20. Open EndedWhat is the consequence of desensitization of cortisol receptors on neurotransmitter function?
- 21. Open EndedList the consequences of chronic hyper secretion of CRF/cortisol (due to stress and subsequent HPA axis activation)
- 22. Open EndedHow do depressed patients respond to the dexamethasone test?
- 23. Open EndedDo depressed patients have more or less CRH (corticotropin releasing hormone) neurons than normal?
- 24. Open EndedWhat is the principal source of brain CRH?
- 25. Open EndedWhat happens in animals if CRF is injected into the brain?
- 26. Open EndedDo depressed patients have larger or smaller pituitary/adrenal glands?
- 27. Open EndedTrue/False: CRH receptor polymorphisms interact with degree of childhood abuse in predicting adult depression scores
- 28. Open EndedTrue/False: Cerebral blood flow studies show a decrease in activity in the amygdala, subgenual PFC, medial thalamus, and other brain centers known to be involved in depression
- 29. Open EndedWhy do antidepressants take so long to work?
- 30. Open EndedTrue/False: There is a positive association between childhood maltreatment and biomarkers of inflammation
- 31. Open EndedIFN-alpha was a drug given to cancer patients but a common side effect was depression. Describe two pathophysiological mechanisms by which this occurred.
- 32. Open EndedWhat can be given before treatment with IFN-alpha to reduce the incidence of depression?
- 33. Open EndedName four neurochemical abnormalities that can cause depression
- 34. Open EndedDecreased volume of which 3 areas of the brain are associated with depression?
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