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- 1. Multiple Choice
Autocrine signalling happens during ------------------- of T helper cells
MHC II binding with TCR
Synthesis of CD28
Differentiation of T helper
None of the above
- 2. Fill in the Blank
Name a costimulatory molecule in T helper activation
- 3. Multiple Choice
Signal 0 is ----------------------
Binding of antigen to MHC II in APC
Presence of specific molecular patterns in presented antigens
Phagosome formation
Transfer of T cells to Secondary lymphoid organs
- 4. Multiple Choice
Conditions required for successful activation of T helper
Presence of signal 0
Presence of inadequate amount of CD28
Presence of CD80 or CD86 in APC
Formation of microclusters of TCR complex in T helper
- 5. Multiple Choice
Examples for professional APCs
T lymphocytes
Dendritic cells
B lymphocytes
Erythrocytes
- 6. Multiple Choice
Signal II leads to anergy or inactivation of T helper when
Inadequate quantity of CD28 is expressed
The APC is presenting an autoantigen
Signal 0 is present
Competitive binding of CTLA 4 with CD80 or CD86
- 7. Multiple Choice
A T lymphocyte which has not encountered an antigen yet
Novice
Small
Stem
Naive
- 8. Multiple Choice
The T helper releases a ------------------- during autocrine signalling
IL-2
IL-3
IL-1
IL-R
- 9. Multiple Choice
The signal helping in verification of the presented Antigen as self or non self
Signal 0
Signal 1
Signal 2
Signal 3
- 10. Multiple Choice
The CD4 is present as part of -------------- in T lymphocytes
CD28 R
TCR complex
Microcomplex
ILR complex
- 11. Multiple Choice
What will happen to the Anergic T helper ?
May bind with B lymphocytes
Will be reabsorbed in the secondary lymphoid organ
Remain in circulation functionless till apoptosis
May get activated when the CD28 is expressed adequately the next time
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