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- 1. Multiple ChoiceOnce a mutation has occurred, it is definitely going to be permanent in the organism.TrueFalse
- 2. Multiple ChoiceA nonsense mutation results in _________.A truncated proteinA slightly altered polypeptide chainA shift in the reading frameThe regulatory sequence being altered.
- 3. Multiple ChoiceWhat type of gene do cancer researchers often "turn off" in order to study cancer?proto-oncogenseoncogenesconstitutive genestumor supressor genes
- 4. Multiple ChoiceBecause some amino acids can be coded for by multiple codons, this type of mutation is possible.Nonsense MutationMissense MutationDegenerate MutationSilent Mutation
- 5. Multiple ChoiceIf below is the wild-type DNA sequence, which one shows a point mutation?
5'-ATTCGC-3'5' - AATTCGC - 3'5'- ATCCGC - 3'5' - ATCGC - 3'5' - ATTCGC - 3' - 6. Multiple ChoiceA base pair substitution can result in all of the following except __________.Missense mutationFrameshift MutationSilent MutationNonsense mutation
- 7. Multiple ChoiceWhat kind of mutation is the result of an insertion?Silent MutationMissense mutationNonsense mutationFrameshift mutation
- 8. Multiple ChoiceIf a nonsense mutation occurred in the gene for the lac repressor, how would it affect the lac operon?The lac operon would be on all the timeThe lac operon would be off all the timeThere would be no change in the expression of the lac operon because the repressor does not affect the operon itself.It would depend on the presence of glucose.
- 9. Multiple ChoiceWhich of these are not changes to a proto-oncogene that would contribute to the development of cancer?retroviral insertionsapoptosismissense mutationschromosomal translocation
- 10. Multiple ChoiceMutations usually _____________Are helpfulAre harmfulAre awesomehappen spontaneously
- 11. Multiple ChoiceWhich type of mutations are heritableMutations in somatic cellsMutations in germ line cellsMutations in germ line cells and somatic cells are both heritable.It depends on the specific mutation.
- 12. Multiple ChoiceUltraviolet light often causes which type of mutation?Missense mutationPyrimidine DimersMethylated DNACancer
- 13. Multiple ChoiceWhat is the most common DNA repair mechanismApoptosisNucleotide Excision RepairMethyl Directed Mismatch RepairAmes Test
- 14. Multiple ChoiceWhat is a neoplasm?A cluster of cells with the same missense mutation.An individual cell that with a missense mutation.A group of cells that has lost the ability to regulate their growth and division.A new clump of cells.
- 15. Multiple ChoiceWhich of these do not contribute to the development of cancer?Constitutive genesproto-oncogenespyrimidine dimerscarcinogens
- 16. Multiple ChoiceA mutation in the promoter could change the amino acid sequence.TrueFalse
- 17. Multiple ChoiceWhat makes silent mutations possible?Gene regulationThe degeneracy of the genetic codePost transcriptional alterationsFrameshifts
- 18. Multiple ChoiceIf there is a mutation that changes one amino acid to another amino acid that is similar in structure, it is possible that the gene product will still be able to perform its original function.TrueFalse
- 19. Multiple ChoiceWhat bio molecule do mutations first manifest themselves in?mRNAProteinsDNAIt could be any of these
- 20. Multiple ChoiceThe gene product is _________Promoter, Operator, Gene, TerminatorPolypeptide ChainDNAOncogenes
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